Drug interactions
Hydrochlorothiazide + Meclofenamate
Severity: Moderate
Hydrochlorothiazide and Meclofenamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as meclofenamate can blunt the antihypertensive and diuretic effects of thiazides through sodium and water retention and reduced renal prostaglandins. The combination may also increase the risk of acute kidney injury, especially with volume depletion or in older patients.
What this interaction means in plain words
Hydrochlorothiazide and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces natriuresis and renal blood flow, antagonizing thiazide effects.
What to do
Monitor blood pressure, renal function and electrolytes, and use the lowest effective NSAID dose for the shortest time; ensure adequate hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Hydrochlorothiazide with Meclofenamate?
MediHelp rates the interaction as moderate. Hydrochlorothiazide and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as meclofenamate can blunt the antihypertensive and diuretic effects of thiazides through sodium and water retention and reduced renal prostaglandins. The combination may also increase the risk of acute kidney injury, especially with volume depletion or in older patients.
How serious is the interaction between Hydrochlorothiazide and Meclofenamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and electrolytes, and use the lowest effective NSAID dose for the shortest time; ensure adequate hydration.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
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