Drug interactions
Hydrochlorothiazide + Metaproterenol
Severity: Moderate
Hydrochlorothiazide and Metaproterenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower serum potassium, and the combination can cause clinically significant hypokalemia. This may predispose to cardiac arrhythmias and ECG changes, particularly with higher beta-agonist doses.
What this interaction means in plain words
Hydrochlorothiazide and Metaproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thiazide urinary potassium loss is additive to beta-2 agonist-driven intracellular potassium shift.
What to do
Monitor serum potassium, particularly when starting therapy or with high beta-agonist doses, and supplement potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Hydrochlorothiazide with Metaproterenol?
MediHelp rates the interaction as moderate. Hydrochlorothiazide and Metaproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower serum potassium, and the combination can cause clinically significant hypokalemia. This may predispose to cardiac arrhythmias and ECG changes, particularly with higher beta-agonist doses.
How serious is the interaction between Hydrochlorothiazide and Metaproterenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, particularly when starting therapy or with high beta-agonist doses, and supplement potassium as needed.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
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