Drug interactions
Hydrochlorothiazide + Mycophenolate
Severity: Minor
Hydrochlorothiazide and Mycophenolate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides may compete for renal tubular secretion of mycophenolic acid glucuronide, potentially raising exposure to this metabolite. The clinical significance is uncertain and typically modest.
What this interaction means in plain words
Hydrochlorothiazide and Mycophenolate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular organic anion secretion of mycophenolic acid glucuronide.
What to do
No dose change is routinely needed; monitor for mycophenolate adverse effects such as cytopenias and GI intolerance.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Hydrochlorothiazide with Mycophenolate?
MediHelp rates the interaction as minor. Hydrochlorothiazide and Mycophenolate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazides may compete for renal tubular secretion of mycophenolic acid glucuronide, potentially raising exposure to this metabolite. The clinical significance is uncertain and typically modest.
How serious is the interaction between Hydrochlorothiazide and Mycophenolate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed; monitor for mycophenolate adverse effects such as cytopenias and GI intolerance.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
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