Drug interactions
Hydrochlorothiazide + Nafcillin
Severity: Minor
Hydrochlorothiazide and Nafcillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are organic anions that may compete for renal tubular secretion, but nafcillin is eliminated mainly by biliary routes. A clinically relevant change in exposure to either drug is unlikely.
What this interaction means in plain words
Hydrochlorothiazide and Nafcillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical competition for renal tubular anion secretion.
What to do
No specific action is required beyond routine monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Hydrochlorothiazide with Nafcillin?
MediHelp rates the interaction as minor. Hydrochlorothiazide and Nafcillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs are organic anions that may compete for renal tubular secretion, but nafcillin is eliminated mainly by biliary routes. A clinically relevant change in exposure to either drug is unlikely.
How serious is the interaction between Hydrochlorothiazide and Nafcillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is required beyond routine monitoring.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
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