Drug interactions
Hydrochlorothiazide + Nitroglycerin rectal
Severity: Moderate
Hydrochlorothiazide and Nitroglycerin rectal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitrates and diuretics both lower blood pressure, and volume depletion from the thiazide can amplify nitrate-induced hypotension. Patients may experience dizziness, orthostasis or syncope.
What this interaction means in plain words
Hydrochlorothiazide and Nitroglycerin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation and volume reduction produce pharmacodynamic hypotension.
What to do
Monitor blood pressure and orthostatic symptoms, and counsel patients to rise slowly; reduce doses if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydrochlorothiazide and Nitroglycerin rectal, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Hydrochlorothiazide with Nitroglycerin rectal?
MediHelp rates the interaction as moderate. Hydrochlorothiazide and Nitroglycerin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitrates and diuretics both lower blood pressure, and volume depletion from the thiazide can amplify nitrate-induced hypotension. Patients may experience dizziness, orthostasis or syncope.
How serious is the interaction between Hydrochlorothiazide and Nitroglycerin rectal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, and counsel patients to rise slowly; reduce doses if symptomatic hypotension occurs.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
