Drug interactions
Hydrochlorothiazide + Olodaterol inhaled
Severity: Moderate
Hydrochlorothiazide and Olodaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can lower serum potassium, and the combination may result in hypokalemia, with possible ECG changes and arrhythmias. Risk is greater at higher beta-agonist doses or with other hypokalemic drugs.
What this interaction means in plain words
Hydrochlorothiazide and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thiazide renal potassium wasting is additive to beta-2 agonist-induced intracellular potassium shift.
What to do
Monitor serum potassium in at-risk patients and correct hypokalemia; use caution if additional QT-prolonging drugs are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Hydrochlorothiazide with Olodaterol inhaled?
MediHelp rates the interaction as moderate. Hydrochlorothiazide and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can lower serum potassium, and the combination may result in hypokalemia, with possible ECG changes and arrhythmias. Risk is greater at higher beta-agonist doses or with other hypokalemic drugs.
How serious is the interaction between Hydrochlorothiazide and Olodaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in at-risk patients and correct hypokalemia; use caution if additional QT-prolonging drugs are present.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
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