Drug interactions
Hydrochlorothiazide + Parecoxib
Severity: Moderate
Hydrochlorothiazide and Parecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as parecoxib can reduce the antihypertensive and diuretic effects of thiazides and increase the risk of acute kidney injury, especially in volume-depleted patients. Fluid retention and hypertension may result.
What this interaction means in plain words
Hydrochlorothiazide and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
COX-2 inhibition reduces renal prostaglandins, causing sodium retention and reduced renal perfusion.
What to do
Maintain hydration and monitor blood pressure, serum creatinine and electrolytes; use the shortest effective parecoxib course.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Hydrochlorothiazide with Parecoxib?
MediHelp rates the interaction as moderate. Hydrochlorothiazide and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as parecoxib can reduce the antihypertensive and diuretic effects of thiazides and increase the risk of acute kidney injury, especially in volume-depleted patients. Fluid retention and hypertension may result.
How serious is the interaction between Hydrochlorothiazide and Parecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Maintain hydration and monitor blood pressure, serum creatinine and electrolytes; use the shortest effective parecoxib course.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
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