Drug interactions
Hydrochlorothiazide + Penicillin vk
Severity: Minor
Hydrochlorothiazide and Penicillin vk: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs undergo renal tubular secretion, so hydrochlorothiazide may slightly reduce penicillin clearance. The effect is small and rarely matters given penicillin's wide safety margin.
What this interaction means in plain words
Hydrochlorothiazide and Penicillin vk have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible competition for renal tubular organic anion secretion.
What to do
No dose change is usually needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Hydrochlorothiazide with Penicillin vk?
MediHelp rates the interaction as minor. Hydrochlorothiazide and Penicillin vk have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs undergo renal tubular secretion, so hydrochlorothiazide may slightly reduce penicillin clearance. The effect is small and rarely matters given penicillin's wide safety margin.
How serious is the interaction between Hydrochlorothiazide and Penicillin vk?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
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