Drug interactions
Hydrochlorothiazide + Propranolol
Severity: Minor
Hydrochlorothiazide and Propranolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propranolol may slightly raise potassium while hydrochlorothiazide lowers it, so the net effect is small. The pair adds to blood pressure lowering, and both can worsen glucose control or mask hypoglycemia symptoms in diabetes.
What this interaction means in plain words
Hydrochlorothiazide and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide belongs to Cardiovascular; Propranolol belongs to Cardiovascular.
Why it happens
Non-selective beta-blockade reduces cellular potassium uptake, offsetting thiazide potassium loss, with additive antihypertensive effects.
What to do
Monitor blood pressure, serum potassium and, in diabetic patients, blood glucose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydrochlorothiazide and Propranolol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Hydrochlorothiazide
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Frequently asked questions
Can I take Hydrochlorothiazide with Propranolol?
MediHelp rates the interaction as minor. Hydrochlorothiazide and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Propranolol may slightly raise potassium while hydrochlorothiazide lowers it, so the net effect is small. The pair adds to blood pressure lowering, and both can worsen glucose control or mask hypoglycemia symptoms in diabetes.
How serious is the interaction between Hydrochlorothiazide and Propranolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum potassium and, in diabetic patients, blood glucose.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
