Drug interactions
Hydrochlorothiazide + Sacubitril / valsartan
Severity: Moderate
Hydrochlorothiazide and Sacubitril / valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combined use is common and generally additive for blood pressure lowering, with a risk of hypotension, renal dysfunction and volume depletion. Valsartan tends to raise potassium while thiazide lowers it, so net effect varies.
What this interaction means in plain words
Hydrochlorothiazide and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effects on blood pressure, volume and renal function with opposing potassium effects.
What to do
Monitor blood pressure, serum creatinine and potassium after initiation and dose changes; adjust the diuretic if hypotension or volume depletion occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Hydrochlorothiazide with Sacubitril / valsartan?
MediHelp rates the interaction as moderate. Hydrochlorothiazide and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combined use is common and generally additive for blood pressure lowering, with a risk of hypotension, renal dysfunction and volume depletion. Valsartan tends to raise potassium while thiazide lowers it, so net effect varies.
How serious is the interaction between Hydrochlorothiazide and Sacubitril / valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium after initiation and dose changes; adjust the diuretic if hypotension or volume depletion occurs.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
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