Drug interactions
Hydrochlorothiazide + Salsalate
Severity: Minor
Hydrochlorothiazide and Salsalate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate has weaker effects on renal prostaglandins than other NSAIDs, but may still reduce thiazide efficacy or affect renal function in susceptible patients. Clinically significant effects are uncommon.
What this interaction means in plain words
Hydrochlorothiazide and Salsalate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Mild inhibition of renal prostaglandin synthesis may attenuate thiazide natriuretic and antihypertensive effects.
What to do
Monitor blood pressure and renal function in elderly or volume-depleted patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Hydrochlorothiazide with Salsalate?
MediHelp rates the interaction as minor. Hydrochlorothiazide and Salsalate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Salsalate has weaker effects on renal prostaglandins than other NSAIDs, but may still reduce thiazide efficacy or affect renal function in susceptible patients. Clinically significant effects are uncommon.
How serious is the interaction between Hydrochlorothiazide and Salsalate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function in elderly or volume-depleted patients.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
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