Drug interactions
Hydrochlorothiazide + Telmisartan
Severity: Minor
Hydrochlorothiazide and Telmisartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Telmisartan tends to raise potassium while hydrochlorothiazide lowers it, so the effects partly offset. The combination is widely used, but hypotension, volume depletion and renal function changes can occur.
What this interaction means in plain words
Hydrochlorothiazide and Telmisartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide belongs to Cardiovascular; Telmisartan belongs to Cardiovascular.
Why it happens
Angiotensin receptor blockade reduces aldosterone-mediated potassium excretion, counteracting thiazide potassium loss.
What to do
Check potassium, creatinine and blood pressure after starting or changing doses. No routine adjustment is needed if stable.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide
Other interactions of Telmisartan
- Aliskiren + Telmisartan Contraindicated
- Sparsentan + Telmisartan Contraindicated
- Amifostine + Telmisartan Major
- Amiloride + Telmisartan Major
- Amlodipine-benazepril + Telmisartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Telmisartan Major
Frequently asked questions
Can I take Hydrochlorothiazide with Telmisartan?
MediHelp rates the interaction as minor. Hydrochlorothiazide and Telmisartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Telmisartan tends to raise potassium while hydrochlorothiazide lowers it, so the effects partly offset. The combination is widely used, but hypotension, volume depletion and renal function changes can occur.
How serious is the interaction between Hydrochlorothiazide and Telmisartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium, creatinine and blood pressure after starting or changing doses. No routine adjustment is needed if stable.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
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