Drug interactions
Hydrochlorothiazide + Ticarcillin
Severity: Moderate
Hydrochlorothiazide and Ticarcillin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticarcillin is given as a sodium salt and can lower serum potassium, so combined use with a thiazide may add to hypokalemia. Low potassium raises the risk of arrhythmia and muscle weakness, particularly with high-dose intravenous therapy.
What this interaction means in plain words
Hydrochlorothiazide and Ticarcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive potassium loss through renal wasting from the thiazide and from the non-reabsorbable anion and sodium load of ticarcillin.
What to do
Check serum potassium and magnesium during high-dose ticarcillin therapy and replace as needed. Take extra care in patients on digoxin or with heart disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Hydrochlorothiazide with Ticarcillin?
MediHelp rates the interaction as moderate. Hydrochlorothiazide and Ticarcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ticarcillin is given as a sodium salt and can lower serum potassium, so combined use with a thiazide may add to hypokalemia. Low potassium raises the risk of arrhythmia and muscle weakness, particularly with high-dose intravenous therapy.
How serious is the interaction between Hydrochlorothiazide and Ticarcillin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and magnesium during high-dose ticarcillin therapy and replace as needed. Take extra care in patients on digoxin or with heart disease.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
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