Drug interactions
Hydrochlorothiazide + Trilostane
Severity: Moderate
Hydrochlorothiazide and Trilostane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trilostane inhibits adrenal steroid synthesis including aldosterone, which reduces potassium loss and may enhance the natriuretic effect. Combined with hydrochlorothiazide, this can cause hyperkalemia, hyponatremia or hypovolemia in susceptible patients.
What this interaction means in plain words
Hydrochlorothiazide and Trilostane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of 3-beta-hydroxysteroid dehydrogenase lowers aldosterone, opposing thiazide-induced potassium loss and adding to sodium loss.
What to do
Monitor serum sodium, potassium, blood pressure and renal function when combining the drugs. Adjust doses or stop the thiazide if electrolyte abnormalities develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Hydrochlorothiazide with Trilostane?
MediHelp rates the interaction as moderate. Hydrochlorothiazide and Trilostane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trilostane inhibits adrenal steroid synthesis including aldosterone, which reduces potassium loss and may enhance the natriuretic effect. Combined with hydrochlorothiazide, this can cause hyperkalemia, hyponatremia or hypovolemia in susceptible patients.
How serious is the interaction between Hydrochlorothiazide and Trilostane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum sodium, potassium, blood pressure and renal function when combining the drugs. Adjust doses or stop the thiazide if electrolyte abnormalities develop.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
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