Drug interactions
Hydrochlorothiazide + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Hydrochlorothiazide and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol, a beta-agonist, can lower serum potassium and prolong the QTc interval, and a thiazide diuretic can add to hypokalaemia. The effect is usually modest at recommended doses but may be significant at higher doses.
What this interaction means in plain words
Hydrochlorothiazide and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypokalaemia from beta-2 stimulated intracellular potassium shift and thiazide renal potassium loss.
What to do
Do not exceed recommended inhaler doses, and monitor serum potassium in patients with risk factors for arrhythmia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Hydrochlorothiazide with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Hydrochlorothiazide and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol, a beta-agonist, can lower serum potassium and prolong the QTc interval, and a thiazide diuretic can add to hypokalaemia. The effect is usually modest at recommended doses but may be significant at higher doses.
How serious is the interaction between Hydrochlorothiazide and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not exceed recommended inhaler doses, and monitor serum potassium in patients with risk factors for arrhythmia.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
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