Drug interactions
Hydrochlorothiazide + Xipamide
Severity: Moderate
Hydrochlorothiazide and Xipamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Xipamide is a thiazide-like diuretic, so adding it to hydrochlorothiazide duplicates therapy. This can cause excessive diuresis, volume depletion, hypokalemia, hyponatremia and hypotension.
What this interaction means in plain words
Hydrochlorothiazide and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive inhibition of the distal tubular sodium-chloride transporter, increasing sodium and potassium loss.
What to do
Avoid routine use of two thiazide-type agents together. If used deliberately, monitor electrolytes, renal function and blood pressure closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydrochlorothiazide and Xipamide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Hydrochlorothiazide with Xipamide?
MediHelp rates the interaction as moderate. Hydrochlorothiazide and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Xipamide is a thiazide-like diuretic, so adding it to hydrochlorothiazide duplicates therapy. This can cause excessive diuresis, volume depletion, hypokalemia, hyponatremia and hypotension.
How serious is the interaction between Hydrochlorothiazide and Xipamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine use of two thiazide-type agents together. If used deliberately, monitor electrolytes, renal function and blood pressure closely.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
