Drug interactions
Hydrochlorothiazide-irbesartan + Hydrocortisone
Severity: Moderate
Hydrochlorothiazide-irbesartan and Hydrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both thiazides and corticosteroids promote potassium loss, so combined use can lead to hypokalemia. This is more likely with prolonged or high-dose steroid therapy and may provoke arrhythmias or weakness.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-irbesartan belongs to Cardiovascular; Hydrocortisone belongs to Endocrine.
Why it happens
Additive renal potassium wasting from thiazide-induced distal sodium delivery and glucocorticoid mineralocorticoid activity.
What to do
Monitor serum potassium periodically and replace potassium as needed. The irbesartan component may partly offset losses but does not remove the need for monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Hydrocortisone?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-irbesartan and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both thiazides and corticosteroids promote potassium loss, so combined use can lead to hypokalemia. This is more likely with prolonged or high-dose steroid therapy and may provoke arrhythmias or weakness.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Hydrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium periodically and replace potassium as needed. The irbesartan component may partly offset losses but does not remove the need for monitoring.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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