Drug interactions
Hydrochlorothiazide-irbesartan + Indacaterol inhaled
Severity: Moderate
Hydrochlorothiazide-irbesartan and Indacaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indacaterol can lower serum potassium, and thiazides add potassium loss, so hypokalemia and ECG changes may occur, particularly at high doses or with hypoxia.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Indacaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta-2 agonist-driven cellular potassium uptake adds to thiazide-induced renal potassium wasting.
What to do
Monitor serum potassium, especially at treatment start or with other potassium-lowering drugs, and correct deficits.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Indacaterol inhaled?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-irbesartan and Indacaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indacaterol can lower serum potassium, and thiazides add potassium loss, so hypokalemia and ECG changes may occur, particularly at high doses or with hypoxia.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Indacaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, especially at treatment start or with other potassium-lowering drugs, and correct deficits.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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