Drug interactions
Hydrochlorothiazide-irbesartan + Indapamide
Severity: Moderate
Hydrochlorothiazide-irbesartan and Indapamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indapamide is a thiazide-like diuretic and combined with hydrochlorothiazide produces duplicate diuretic therapy. This increases the risk of hypotension, hyponatremia, hypokalemia, and renal impairment, with irbesartan adding to the risk of renal dysfunction in volume depletion.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-irbesartan belongs to Cardiovascular; Indapamide belongs to Cardiovascular.
Why it happens
Additive inhibition of the distal tubular sodium-chloride cotransporter, with ARB-related reduction of glomerular filtration pressure.
What to do
Avoid combining two thiazide-type diuretics unless specifically intended, and monitor sodium, potassium, creatinine and blood pressure if both are used. Consider stopping one agent.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Indapamide
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Indapamide?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-irbesartan and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indapamide is a thiazide-like diuretic and combined with hydrochlorothiazide produces duplicate diuretic therapy. This increases the risk of hypotension, hyponatremia, hypokalemia, and renal impairment, with irbesartan adding to the risk of renal dysfunction in volume depletion.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Indapamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two thiazide-type diuretics unless specifically intended, and monitor sodium, potassium, creatinine and blood pressure if both are used. Consider stopping one agent.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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