Drug interactions
Hydrochlorothiazide-irbesartan + Insulin aspart protamine / insulin aspart
Severity: Minor
Hydrochlorothiazide-irbesartan and Insulin aspart protamine / insulin aspart: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angiotensin receptor blockers may enhance insulin sensitivity and increase the risk of hypoglycemia in patients on insulin. Hydrochlorothiazide may have the opposite effect and raise glucose.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Insulin aspart protamine / insulin aspart have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
ARBs may improve insulin sensitivity, while thiazides impair glucose tolerance.
What to do
Monitor blood glucose when starting or changing the combination and adjust insulin dose as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Insulin aspart protamine / insulin aspart?
MediHelp rates the interaction as minor. Hydrochlorothiazide-irbesartan and Insulin aspart protamine / insulin aspart have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Angiotensin receptor blockers may enhance insulin sensitivity and increase the risk of hypoglycemia in patients on insulin. Hydrochlorothiazide may have the opposite effect and raise glucose.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Insulin aspart protamine / insulin aspart?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or changing the combination and adjust insulin dose as needed.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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