Drug interactions
Hydrochlorothiazide-irbesartan + Insulin degludec / insulin aspart
Severity: Minor
Hydrochlorothiazide-irbesartan and Insulin degludec / insulin aspart: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide can raise blood glucose and reduce the effect of insulin, while irbesartan may slightly increase insulin sensitivity. The overall effect varies and may call for dose changes.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Insulin degludec / insulin aspart have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Thiazide-induced insulin resistance and hypokalemia-related reduced insulin release oppose insulin, while ARBs may improve insulin sensitivity.
What to do
Monitor glucose when starting, stopping or changing doses and adjust insulin as needed; check potassium.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Insulin degludec / insulin aspart?
MediHelp rates the interaction as minor. Hydrochlorothiazide-irbesartan and Insulin degludec / insulin aspart have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide can raise blood glucose and reduce the effect of insulin, while irbesartan may slightly increase insulin sensitivity. The overall effect varies and may call for dose changes.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Insulin degludec / insulin aspart?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose when starting, stopping or changing doses and adjust insulin as needed; check potassium.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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