Drug interactions
Hydrochlorothiazide-irbesartan + Insulin detemir
Severity: Minor
Hydrochlorothiazide-irbesartan and Insulin detemir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angiotensin receptor blockers may modestly improve insulin sensitivity and enhance glucose lowering, while thiazides can raise blood glucose. The net effect on glycemic control is variable, and hypoglycemia or hyperglycemia may occur.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Insulin detemir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-irbesartan belongs to Cardiovascular; Insulin detemir belongs to Endocrine.
Why it happens
ARBs may improve insulin sensitivity while thiazide-induced hypokalemia and reduced insulin secretion can worsen glycemia; the net effect is not well defined.
What to do
Monitor blood glucose more often after starting or changing the antihypertensive and adjust insulin dose as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Insulin detemir
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Insulin detemir?
MediHelp rates the interaction as minor. Hydrochlorothiazide-irbesartan and Insulin detemir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Angiotensin receptor blockers may modestly improve insulin sensitivity and enhance glucose lowering, while thiazides can raise blood glucose. The net effect on glycemic control is variable, and hypoglycemia or hyperglycemia may occur.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Insulin detemir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often after starting or changing the antihypertensive and adjust insulin dose as needed.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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