Drug interactions
Hydrochlorothiazide-irbesartan + Insulin inhaled
Severity: Minor
Hydrochlorothiazide-irbesartan and Insulin inhaled: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide can raise blood glucose and reduce the effect of inhaled insulin in patients with diabetes. Irbesartan may slightly enhance insulin sensitivity.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Insulin inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Thiazide-induced impairment of glucose tolerance and insulin secretion opposes insulin action.
What to do
Monitor glucose when the thiazide is started or changed and adjust insulin dose as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Insulin inhaled?
MediHelp rates the interaction as minor. Hydrochlorothiazide-irbesartan and Insulin inhaled have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide can raise blood glucose and reduce the effect of inhaled insulin in patients with diabetes. Irbesartan may slightly enhance insulin sensitivity.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Insulin inhaled?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose when the thiazide is started or changed and adjust insulin dose as needed.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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