Drug interactions
Hydrochlorothiazide-irbesartan + Insulin lispro protamine / insulin lispro
Severity: Moderate
Hydrochlorothiazide-irbesartan and Insulin lispro protamine / insulin lispro: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angiotensin receptor blockers can improve insulin sensitivity and may enhance the glucose-lowering effect of insulin, occasionally causing hypoglycemia. Thiazide diuretics may work in the opposite direction by raising blood glucose. The net effect on glycemic control is variable.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Insulin lispro protamine / insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
ARBs may increase insulin sensitivity, while thiazides can impair glucose tolerance; the combined effect is not well characterized.
What to do
Monitor blood glucose more frequently when starting, stopping or changing the dose of the combination product. Adjust the insulin dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Insulin lispro protamine / insulin lispro?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-irbesartan and Insulin lispro protamine / insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Angiotensin receptor blockers can improve insulin sensitivity and may enhance the glucose-lowering effect of insulin, occasionally causing hypoglycemia. Thiazide diuretics may work in the opposite direction by raising blood glucose. The net effect on glycemic control is variable.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Insulin lispro protamine / insulin lispro?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when starting, stopping or changing the dose of the combination product. Adjust the insulin dose as needed.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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