Drug interactions
Hydrochlorothiazide-irbesartan + Metformin
Severity: Minor
Hydrochlorothiazide-irbesartan and Metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides can raise blood glucose and reduce the effectiveness of metformin. Diuretic-related volume depletion and reduced renal function may also raise metformin exposure and the risk of lactic acidosis.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-irbesartan belongs to Cardiovascular; Metformin belongs to Endocrine.
Why it happens
Thiazide-induced hyperglycemia opposes metformin; reduced renal clearance may increase metformin levels.
What to do
Monitor glucose control and renal function, adjusting metformin if eGFR falls. Watch for dehydration.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Metformin
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Metformin?
MediHelp rates the interaction as minor. Hydrochlorothiazide-irbesartan and Metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazides can raise blood glucose and reduce the effectiveness of metformin. Diuretic-related volume depletion and reduced renal function may also raise metformin exposure and the risk of lactic acidosis.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose control and renal function, adjusting metformin if eGFR falls. Watch for dehydration.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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