Drug interactions
Hydrochlorothiazide-irbesartan + Methotrexate
Severity: Moderate
Hydrochlorothiazide-irbesartan and Methotrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides can reduce renal clearance of methotrexate and may deepen myelosuppression. The risk is greater with high-dose methotrexate or reduced renal function, and ARB plus diuretic can further impair renal function.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-irbesartan belongs to Cardiovascular; Methotrexate belongs to Oncology.
Why it happens
Reduced renal elimination of methotrexate, with possible volume depletion and reduced glomerular filtration.
What to do
Monitor complete blood counts and renal function closely, especially with higher methotrexate doses. Consider an alternative antihypertensive during high-dose therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Methotrexate?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-irbesartan and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazides can reduce renal clearance of methotrexate and may deepen myelosuppression. The risk is greater with high-dose methotrexate or reduced renal function, and ARB plus diuretic can further impair renal function.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Methotrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and renal function closely, especially with higher methotrexate doses. Consider an alternative antihypertensive during high-dose therapy.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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