Drug interactions
Hydrochlorothiazide-irbesartan + Methyclothiazide
Severity: Moderate
Hydrochlorothiazide-irbesartan and Methyclothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This is a therapeutic duplication, since the product already contains hydrochlorothiazide. Adding a second thiazide increases the risk of volume depletion, hypokalemia, hyponatremia, hyperuricemia and hypotension, with little added antihypertensive benefit.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Duplicate inhibition of the distal tubule sodium-chloride cotransporter produces additive diuretic and electrolyte effects.
What to do
Avoid using two thiazides together. If more diuresis is needed, consider a different class, and monitor electrolytes, renal function and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Methyclothiazide?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-irbesartan and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. This is a therapeutic duplication, since the product already contains hydrochlorothiazide. Adding a second thiazide increases the risk of volume depletion, hypokalemia, hyponatremia, hyperuricemia and hypotension, with little added antihypertensive benefit.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Methyclothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two thiazides together. If more diuresis is needed, consider a different class, and monitor electrolytes, renal function and blood pressure.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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