Drug interactions
Hydrochlorothiazide-irbesartan + Methyl aminolevulinate
Severity: Moderate
Hydrochlorothiazide-irbesartan and Methyl aminolevulinate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide is a photosensitising drug, and methyl aminolevulinate is used topically for photodynamic therapy. Combining them may theoretically intensify skin phototoxicity, though systemic absorption of the topical agent is low.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Methyl aminolevulinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive photosensitisation from systemic hydrochlorothiazide and photodynamic activity of the porphyrin generated from methyl aminolevulinate.
What to do
Counsel the patient on strict sun protection and inspect the treated site for exaggerated reactions after illumination; consider timing therapy when the thiazide can be safely held if reactions occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Methyl aminolevulinate?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-irbesartan and Methyl aminolevulinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide is a photosensitising drug, and methyl aminolevulinate is used topically for photodynamic therapy. Combining them may theoretically intensify skin phototoxicity, though systemic absorption of the topical agent is low.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Methyl aminolevulinate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient on strict sun protection and inspect the treated site for exaggerated reactions after illumination; consider timing therapy when the thiazide can be safely held if reactions occur.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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