Drug interactions
Hydrochlorothiazide-irbesartan + Nirmatrelvir / ritonavir
Severity: Minor
Hydrochlorothiazide-irbesartan and Nirmatrelvir / ritonavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir may weakly induce CYP2C9 and could slightly reduce irbesartan exposure. Because nirmatrelvir/ritonavir is given for only five days, induction is unlikely to reach a clinically important level.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Nirmatrelvir / ritonavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak CYP2C9 induction by ritonavir increasing irbesartan metabolism.
What to do
No dose change is needed; monitor blood pressure as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Nirmatrelvir / ritonavir?
MediHelp rates the interaction as minor. Hydrochlorothiazide-irbesartan and Nirmatrelvir / ritonavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ritonavir may weakly induce CYP2C9 and could slightly reduce irbesartan exposure. Because nirmatrelvir/ritonavir is given for only five days, induction is unlikely to reach a clinically important level.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Nirmatrelvir / ritonavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor blood pressure as usual.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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