Drug interactions
Hydrochlorothiazide-irbesartan + Nitroglycerin rectal
Severity: Moderate
Hydrochlorothiazide-irbesartan and Nitroglycerin rectal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitroglycerin is a vasodilator, and its hypotensive effect adds to that of irbesartan and hydrochlorothiazide. Patients may develop dizziness, syncope or falls, particularly when volume depleted.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Nitroglycerin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation and reduced preload and blood pressure from different mechanisms.
What to do
Monitor blood pressure, including on standing, when starting or increasing nitroglycerin. Reduce the antihypertensive dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Nitroglycerin rectal?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-irbesartan and Nitroglycerin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitroglycerin is a vasodilator, and its hypotensive effect adds to that of irbesartan and hydrochlorothiazide. Patients may develop dizziness, syncope or falls, particularly when volume depleted.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Nitroglycerin rectal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, including on standing, when starting or increasing nitroglycerin. Reduce the antihypertensive dose if symptomatic hypotension occurs.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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