Drug interactions
Hydrochlorothiazide-irbesartan + Noni juice
Severity: Moderate
Hydrochlorothiazide-irbesartan and Noni juice: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Noni juice has a high potassium content, and irbesartan reduces potassium excretion, so hyperkalemia is possible, especially with renal impairment. The potassium-wasting effect of hydrochlorothiazide partly offsets this.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Noni juice can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Dietary potassium load combined with angiotensin receptor blocker-mediated potassium retention.
What to do
Advise patients with kidney disease to avoid regular noni juice, and monitor serum potassium if it is consumed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Noni juice?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-irbesartan and Noni juice can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Noni juice has a high potassium content, and irbesartan reduces potassium excretion, so hyperkalemia is possible, especially with renal impairment. The potassium-wasting effect of hydrochlorothiazide partly offsets this.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Noni juice?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients with kidney disease to avoid regular noni juice, and monitor serum potassium if it is consumed.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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