Drug interactions
Hydrochlorothiazide-irbesartan + Olmesartan
Severity: Major
Hydrochlorothiazide-irbesartan and Olmesartan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding olmesartan to a product that already contains irbesartan gives dual angiotensin receptor blockade with no added benefit. It increases the risk of hypotension, hyperkalemia and renal impairment.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Olmesartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Hydrochlorothiazide-irbesartan belongs to Cardiovascular; Olmesartan belongs to Cardiovascular.
Why it happens
Duplicate blockade of the angiotensin II type 1 receptor produces additive reduction of aldosterone effect and renal efferent tone.
What to do
Avoid combining two ARBs and use a single agent at an optimized dose. If both have been taken, monitor potassium, creatinine and blood pressure and stop one.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Hydrochlorothiazide-irbesartan and Olmesartan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Olmesartan?
MediHelp rates the interaction as major. Hydrochlorothiazide-irbesartan and Olmesartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Adding olmesartan to a product that already contains irbesartan gives dual angiotensin receptor blockade with no added benefit. It increases the risk of hypotension, hyperkalemia and renal impairment.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Olmesartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two ARBs and use a single agent at an optimized dose. If both have been taken, monitor potassium, creatinine and blood pressure and stop one.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
