Drug interactions
Hydrochlorothiazide-irbesartan + Olodaterol inhaled
Severity: Moderate
Hydrochlorothiazide-irbesartan and Olodaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-2 agonists and thiazide diuretics can each lower serum potassium. The combination may cause hypokalemia and increase arrhythmia risk, although the effect is less pronounced with inhaled long-acting agents at usual doses.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta-2 stimulation shifts potassium into cells while thiazides increase renal potassium loss, giving additive hypokalemia.
What to do
Monitor serum potassium, particularly in patients with other risk factors for hypokalemia. Replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Olodaterol inhaled?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-irbesartan and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta-2 agonists and thiazide diuretics can each lower serum potassium. The combination may cause hypokalemia and increase arrhythmia risk, although the effect is less pronounced with inhaled long-acting agents at usual doses.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Olodaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, particularly in patients with other risk factors for hypokalemia. Replace potassium as needed.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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