Drug interactions
Hydrochlorothiazide-irbesartan + Paclitaxel protein bound
Severity: Minor
Hydrochlorothiazide-irbesartan and Paclitaxel protein bound: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Irbesartan is a weak CYP2C8 substrate/inhibitor in vitro, but there is no convincing clinical evidence that it meaningfully raises paclitaxel exposure. The clinical relevance of this pairing is uncertain and the interaction is largely theoretical.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Paclitaxel protein bound have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak inhibition of CYP2C8-mediated paclitaxel metabolism, not established clinically.
What to do
No dose change is generally needed; monitor for paclitaxel toxicity such as neutropenia and neuropathy as per routine care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Paclitaxel protein bound?
MediHelp rates the interaction as minor. Hydrochlorothiazide-irbesartan and Paclitaxel protein bound have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Irbesartan is a weak CYP2C8 substrate/inhibitor in vitro, but there is no convincing clinical evidence that it meaningfully raises paclitaxel exposure. The clinical relevance of this pairing is uncertain and the interaction is largely theoretical.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Paclitaxel protein bound?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; monitor for paclitaxel toxicity such as neutropenia and neuropathy as per routine care.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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