Drug interactions
Hydrochlorothiazide-irbesartan + Penicillin g aqueous
Severity: Minor
Hydrochlorothiazide-irbesartan and Penicillin g aqueous: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides may compete with penicillins for renal tubular secretion, which could modestly raise penicillin concentrations. This is rarely clinically important because penicillins have a wide therapeutic margin.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Penicillin g aqueous have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular organic anion secretion reduces penicillin clearance.
What to do
No routine adjustment is needed; consider monitoring for penicillin adverse effects when high doses are given, particularly in renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Penicillin g aqueous?
MediHelp rates the interaction as minor. Hydrochlorothiazide-irbesartan and Penicillin g aqueous have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazides may compete with penicillins for renal tubular secretion, which could modestly raise penicillin concentrations. This is rarely clinically important because penicillins have a wide therapeutic margin.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Penicillin g aqueous?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; consider monitoring for penicillin adverse effects when high doses are given, particularly in renal impairment.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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