Drug interactions
Hydrochlorothiazide-irbesartan + Penicillin vk
Severity: Minor
Hydrochlorothiazide-irbesartan and Penicillin vk: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide and penicillins are both secreted by renal organic anion pathways, so competition may modestly raise penicillin levels. The clinical effect is small given penicillin's wide therapeutic margin.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Penicillin vk have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular anion secretion.
What to do
No routine action is required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Penicillin vk?
MediHelp rates the interaction as minor. Hydrochlorothiazide-irbesartan and Penicillin vk have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide and penicillins are both secreted by renal organic anion pathways, so competition may modestly raise penicillin levels. The clinical effect is small given penicillin's wide therapeutic margin.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Penicillin vk?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is required.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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