Drug interactions
Hydrochlorothiazide-irbesartan + Potassium citrate / citric acid
Severity: Moderate
Hydrochlorothiazide-irbesartan and Potassium citrate / citric acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Irbesartan reduces aldosterone-mediated potassium excretion, and potassium supplements add to the potassium load. This can cause clinically significant hyperkalemia, particularly in patients with renal impairment or diabetes. The hydrochlorothiazide component may partly offset the effect.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Potassium citrate / citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive increase in serum potassium through angiotensin receptor blockade and exogenous potassium intake.
What to do
Monitor serum potassium and renal function regularly after starting or changing the potassium dose. Reduce or stop the supplement if potassium becomes elevated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Potassium citrate / citric acid?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-irbesartan and Potassium citrate / citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Irbesartan reduces aldosterone-mediated potassium excretion, and potassium supplements add to the potassium load. This can cause clinically significant hyperkalemia, particularly in patients with renal impairment or diabetes. The hydrochlorothiazide component may partly offset the effect.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Potassium citrate / citric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function regularly after starting or changing the potassium dose. Reduce or stop the supplement if potassium becomes elevated.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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