Drug interactions
Hydrochlorothiazide-irbesartan + Propranolol
Severity: Minor
Hydrochlorothiazide-irbesartan and Propranolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propranolol adds to the blood pressure lowering of irbesartan and hydrochlorothiazide, which may cause hypotension or bradycardia. Beta-blockade can also mask hypoglycemia symptoms while thiazides may worsen glucose control.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-irbesartan belongs to Cardiovascular; Propranolol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic antihypertensive effects via beta-blockade, angiotensin receptor blockade and diuresis.
What to do
Monitor blood pressure and heart rate when starting or changing doses. Check potassium and glucose periodically, especially in diabetic patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Propranolol?
MediHelp rates the interaction as minor. Hydrochlorothiazide-irbesartan and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Propranolol adds to the blood pressure lowering of irbesartan and hydrochlorothiazide, which may cause hypotension or bradycardia. Beta-blockade can also mask hypoglycemia symptoms while thiazides may worsen glucose control.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Propranolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or changing doses. Check potassium and glucose periodically, especially in diabetic patients.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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