Drug interactions
Hydrochlorothiazide-irbesartan + Salicylates
Severity: Moderate
Hydrochlorothiazide-irbesartan and Salicylates: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-acetylated salicylates have NSAID-like effects that may weaken the antihypertensive effect of irbesartan and hydrochlorothiazide and contribute to renal function decline in volume-depleted or elderly patients. Effects on potassium are variable.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandins reduces renal perfusion and sodium excretion, opposing antihypertensive and diuretic action.
What to do
Monitor blood pressure, renal function and potassium, and maintain hydration. Prefer acetaminophen where suitable for analgesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Salicylates?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-irbesartan and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Non-acetylated salicylates have NSAID-like effects that may weaken the antihypertensive effect of irbesartan and hydrochlorothiazide and contribute to renal function decline in volume-depleted or elderly patients. Effects on potassium are variable.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Salicylates?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and potassium, and maintain hydration. Prefer acetaminophen where suitable for analgesia.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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