Drug interactions
Hydrochlorothiazide-irbesartan + Salsalate
Severity: Moderate
Hydrochlorothiazide-irbesartan and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate has NSAID-like properties and can reduce the blood pressure effect of irbesartan and hydrochlorothiazide. Together with an ARB and diuretic it may impair renal function, particularly in elderly or dehydrated patients.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Prostaglandin synthesis inhibition reduces renal blood flow and sodium excretion, adding to the hemodynamic renal effects of ARB and diuretic therapy.
What to do
Monitor blood pressure, serum creatinine and potassium, and ensure hydration. Use the lowest effective salsalate dose or choose an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Salsalate?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-irbesartan and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate has NSAID-like properties and can reduce the blood pressure effect of irbesartan and hydrochlorothiazide. Together with an ARB and diuretic it may impair renal function, particularly in elderly or dehydrated patients.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium, and ensure hydration. Use the lowest effective salsalate dose or choose an alternative analgesic.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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