Drug interactions
Hydrochlorothiazide-irbesartan + Shark cartilage
Severity: Moderate
Hydrochlorothiazide-irbesartan and Shark cartilage: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Shark cartilage contains calcium and has been associated with hypercalcemia, and thiazides reduce urinary calcium excretion. Together they could raise serum calcium, although the evidence is largely theoretical.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Shark cartilage can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Calcium load combined with thiazide-induced reduction in renal calcium excretion.
What to do
Avoid shark cartilage supplements where possible, or monitor serum calcium periodically if the patient continues them.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Shark cartilage?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-irbesartan and Shark cartilage can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Shark cartilage contains calcium and has been associated with hypercalcemia, and thiazides reduce urinary calcium excretion. Together they could raise serum calcium, although the evidence is largely theoretical.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Shark cartilage?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid shark cartilage supplements where possible, or monitor serum calcium periodically if the patient continues them.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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