Drug interactions
Hydrochlorothiazide-irbesartan + Synthetic human angiotensin ii
Severity: Moderate
Hydrochlorothiazide-irbesartan and Synthetic human angiotensin ii: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Irbesartan blocks the AT1 receptor, so the pressor response to exogenous angiotensin II may be reduced. This can make angiotensin II less effective in raising blood pressure in vasodilatory shock.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Synthetic human angiotensin ii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competitive antagonism of angiotensin II at the AT1 receptor.
What to do
Monitor blood pressure response closely and expect higher angiotensin II requirements in patients recently taking irbesartan; titrate to effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Synthetic human angiotensin ii?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-irbesartan and Synthetic human angiotensin ii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Irbesartan blocks the AT1 receptor, so the pressor response to exogenous angiotensin II may be reduced. This can make angiotensin II less effective in raising blood pressure in vasodilatory shock.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Synthetic human angiotensin ii?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure response closely and expect higher angiotensin II requirements in patients recently taking irbesartan; titrate to effect.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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