Drug interactions
Hydrochlorothiazide-irbesartan + Terbutaline
Severity: Moderate
Hydrochlorothiazide-irbesartan and Terbutaline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Terbutaline can lower serum potassium, and hydrochlorothiazide in the same product adds further potassium loss. Hypokalemia may provoke arrhythmias, especially with high-dose or nebulized beta-agonist use.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-irbesartan belongs to Cardiovascular; Terbutaline belongs to Respiratory.
Why it happens
Beta-2 stimulation shifts potassium into cells while the thiazide increases urinary potassium loss, producing additive hypokalemia.
What to do
Monitor serum potassium when terbutaline is used at high doses or in patients with cardiac disease. Replace potassium if low.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Terbutaline
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Terbutaline?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-irbesartan and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Terbutaline can lower serum potassium, and hydrochlorothiazide in the same product adds further potassium loss. Hypokalemia may provoke arrhythmias, especially with high-dose or nebulized beta-agonist use.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Terbutaline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium when terbutaline is used at high doses or in patients with cardiac disease. Replace potassium if low.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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