Drug interactions
Hydrochlorothiazide-irbesartan + Ticarcillin
Severity: Minor
Hydrochlorothiazide-irbesartan and Ticarcillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides may slightly reduce renal clearance of ticarcillin, but the effect is small. Ticarcillin contains a sodium load and can also lower potassium, which may add to thiazide-related hypokalemia.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Ticarcillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for tubular secretion, plus additive potassium loss.
What to do
Monitor serum potassium during ticarcillin therapy; no dose adjustment is usually needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Ticarcillin?
MediHelp rates the interaction as minor. Hydrochlorothiazide-irbesartan and Ticarcillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazides may slightly reduce renal clearance of ticarcillin, but the effect is small. Ticarcillin contains a sodium load and can also lower potassium, which may add to thiazide-related hypokalemia.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Ticarcillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium during ticarcillin therapy; no dose adjustment is usually needed.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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