Drug interactions
Hydrochlorothiazide-irbesartan + Vilanterol / fluticasone furoate inhaled
Severity: Moderate
Hydrochlorothiazide-irbesartan and Vilanterol / fluticasone furoate inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol, a beta-agonist, can lower serum potassium and prolong the QT interval, and hydrochlorothiazide also causes potassium loss. The combination may increase the risk of hypokalemia and arrhythmia, especially at higher doses.
What this interaction means in plain words
Hydrochlorothiazide-irbesartan and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypokalemia from beta2-agonist-driven intracellular potassium shift and thiazide renal potassium loss.
What to do
Monitor serum potassium in patients with risk factors such as cardiac disease or high bronchodilator doses. Correct hypokalemia and avoid exceeding recommended inhaler doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Frequently asked questions
Can I take Hydrochlorothiazide-irbesartan with Vilanterol / fluticasone furoate inhaled?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-irbesartan and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol, a beta-agonist, can lower serum potassium and prolong the QT interval, and hydrochlorothiazide also causes potassium loss. The combination may increase the risk of hypokalemia and arrhythmia, especially at higher doses.
How serious is the interaction between Hydrochlorothiazide-irbesartan and Vilanterol / fluticasone furoate inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in patients with risk factors such as cardiac disease or high bronchodilator doses. Correct hypokalemia and avoid exceeding recommended inhaler doses.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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