Drug interactions
Hydrochlorothiazide-lisinopril + Ibuprofen
Severity: Major
Hydrochlorothiazide-lisinopril and Ibuprofen: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibuprofen can reduce the antihypertensive effect of the thiazide and ACE inhibitor. Combined with a diuretic and ACE inhibitor it increases the risk of acute kidney injury and hyperkalemia, especially in dehydrated, elderly or renally impaired patients.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Ibuprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Hydrochlorothiazide-lisinopril belongs to Cardiovascular; Ibuprofen belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal perfusion and sodium excretion, opposing the diuretic and ACE inhibitor.
What to do
Avoid regular use where possible and prefer paracetamol. If an NSAID is needed, use the lowest dose briefly and monitor blood pressure, creatinine and potassium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Ibuprofen?
MediHelp rates the interaction as major. Hydrochlorothiazide-lisinopril and Ibuprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ibuprofen can reduce the antihypertensive effect of the thiazide and ACE inhibitor. Combined with a diuretic and ACE inhibitor it increases the risk of acute kidney injury and hyperkalemia, especially in dehydrated, elderly or renally impaired patients.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Ibuprofen?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular use where possible and prefer paracetamol. If an NSAID is needed, use the lowest dose briefly and monitor blood pressure, creatinine and potassium.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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