Drug interactions
Hydrochlorothiazide-lisinopril + Insulin degludec
Severity: Moderate
Hydrochlorothiazide-lisinopril and Insulin degludec: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can impair glucose tolerance and may reduce the glucose lowering effect of insulin. Conversely, ACE inhibitors can improve insulin sensitivity and occasionally increase hypoglycemia risk.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-lisinopril belongs to Cardiovascular; Insulin degludec belongs to Endocrine.
Why it happens
Thiazides reduce insulin secretion and sensitivity, partly through hypokalemia, while ACE inhibitors may enhance insulin sensitivity.
What to do
Monitor blood glucose after starting or changing the thiazide or ACE inhibitor and adjust the insulin dose as needed. Keep potassium in the normal range.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Insulin degludec
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Insulin degludec?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-lisinopril and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics can impair glucose tolerance and may reduce the glucose lowering effect of insulin. Conversely, ACE inhibitors can improve insulin sensitivity and occasionally increase hypoglycemia risk.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Insulin degludec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or changing the thiazide or ACE inhibitor and adjust the insulin dose as needed. Keep potassium in the normal range.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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