Drug interactions
Hydrochlorothiazide-lisinopril + Insulin glulisine
Severity: Minor
Hydrochlorothiazide-lisinopril and Insulin glulisine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides can raise blood glucose and reduce the effect of insulin, so insulin requirements may rise. Conversely, ACE inhibitors may enhance insulin sensitivity, so the net effect varies.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Insulin glulisine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-lisinopril belongs to Cardiovascular; Insulin glulisine belongs to Endocrine.
Why it happens
Thiazide-induced impairment of insulin secretion and sensitivity opposes insulin action.
What to do
Monitor blood glucose when starting or changing the combination and adjust insulin doses accordingly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Insulin glulisine
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Insulin glulisine?
MediHelp rates the interaction as minor. Hydrochlorothiazide-lisinopril and Insulin glulisine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazides can raise blood glucose and reduce the effect of insulin, so insulin requirements may rise. Conversely, ACE inhibitors may enhance insulin sensitivity, so the net effect varies.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Insulin glulisine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or changing the combination and adjust insulin doses accordingly.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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