Drug interactions
Hydrochlorothiazide-lisinopril + Lofexidine
Severity: Moderate
Hydrochlorothiazide-lisinopril and Lofexidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofexidine lowers blood pressure and heart rate, and its effects add to those of antihypertensives such as hydrochlorothiazide and lisinopril. Patients may develop hypotension, dizziness and syncope. Volume depletion from the diuretic further increases the risk.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrochlorothiazide-lisinopril belongs to Cardiovascular; Lofexidine belongs to Central Nervous System.
Why it happens
Additive hypotensive effects from central alpha-2 agonism with diuretic and ACE inhibitor action.
What to do
Monitor blood pressure and pulse when starting lofexidine and during dose changes. Reduce or hold antihypertensives if symptomatic hypotension or bradycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Lofexidine?
MediHelp rates the interaction as moderate. Hydrochlorothiazide-lisinopril and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofexidine lowers blood pressure and heart rate, and its effects add to those of antihypertensives such as hydrochlorothiazide and lisinopril. Patients may develop hypotension, dizziness and syncope. Volume depletion from the diuretic further increases the risk.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Lofexidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and pulse when starting lofexidine and during dose changes. Reduce or hold antihypertensives if symptomatic hypotension or bradycardia occurs.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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