Drug interactions
Hydrochlorothiazide-lisinopril + Magnesium citrate
Severity: Minor
Hydrochlorothiazide-lisinopril and Magnesium citrate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics increase urinary magnesium loss, so long-term use can lower serum magnesium. Occasional oral magnesium citrate as a laxative is unlikely to matter, though regular supplementation may partly offset the loss.
What this interaction means in plain words
Hydrochlorothiazide-lisinopril and Magnesium citrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrochlorothiazide-lisinopril belongs to Cardiovascular; Magnesium citrate belongs to Gastrointestinal Tract.
Why it happens
Thiazides increase renal magnesium excretion, which may reduce magnesium status.
What to do
No routine action is needed; check serum magnesium in patients on long-term thiazide therapy with symptoms or risk of deficiency.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Magnesium citrate
- Ciprofloxacin + Magnesium citrate Major
- Baloxavir marboxil + Magnesium citrate Moderate
- Bictegravir + Magnesium citrate Moderate
- Cabotegravir + Magnesium citrate Moderate
- Cholecalciferol + Magnesium citrate Moderate
- Deferiprone + Magnesium citrate Moderate
Frequently asked questions
Can I take Hydrochlorothiazide-lisinopril with Magnesium citrate?
MediHelp rates the interaction as minor. Hydrochlorothiazide-lisinopril and Magnesium citrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics increase urinary magnesium loss, so long-term use can lower serum magnesium. Occasional oral magnesium citrate as a laxative is unlikely to matter, though regular supplementation may partly offset the loss.
How serious is the interaction between Hydrochlorothiazide-lisinopril and Magnesium citrate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; check serum magnesium in patients on long-term thiazide therapy with symptoms or risk of deficiency.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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